Phenotypes for Cadps Ptf1a MGI:5562545 MGI Mouse

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Phenotypes Associated with This Genotype

Allelic Composition	Cadps^tm1.1Tfr/Cadps^tm1.2Tfr Ptf1a^{tm1.1(cre)Cvw}/Ptf1a⁺
Genetic Background	B6.Cg-Ptf1a^{tm1.1(cre)Cvw} Cadps^tm1.1Tfr Cadps^tm1.2Tfr

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cadps^tm1.1Tfr mutation (1 available); any Cadps mutation (69 available)
Cadps^tm1.2Tfr mutation (0 available); any Cadps mutation (69 available)
Ptf1a^{tm1.1(cre)Cvw} mutation (1 available); any Ptf1a mutation (29 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

nervous system

nervous system phenotype ( J:204664 )

N	• normal basic synaptic transmission, short-term plasticity, and climber-fiber-Purkinje innervation

abnormal synaptic vesicle number ( J:204664 )

• reduction in the number of synaptic vesicles per presynapse

abnormal cerebellar molecular layer ( J:204664 )

• decrease in the density of BDNF+ climbing fibers

• reduction of dense core vesicle density in the presynaptic area and a decrease in the number of synaptic vesicles per presynapse

abnormal synaptic bouton morphology ( J:204664 )

• reduction of dense core vesicle density in the presynaptic area

decreased excitatory postsynaptic current amplitude ( J:204664 )

• decrease in climbing fiber-EPSC amplitude

abnormal paired-pulse inhibition ( J:204664 )

• enhanced paired-pulse depression of climbing fiber EPSCs

cellular

abnormal synaptic vesicle number ( J:204664 )

• reduction in the number of synaptic vesicles per presynapse

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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