Phenotypes for Cadps Emx1 MGI:5562543 MGI Mouse

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Phenotypes Associated with This Genotype

Allelic Composition	Cadps^tm1.1Tfr/Cadps^tm1.2Tfr Emx1^tm1(cre)Ito/Emx1⁺
Genetic Background	B6.Cg-Emx1^tm1(cre)Ito Cadps^tm1.1Tfr Cadps^tm1.2Tfr

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cadps^tm1.1Tfr mutation (1 available); any Cadps mutation (69 available)
Cadps^tm1.2Tfr mutation (0 available); any Cadps mutation (69 available)
Emx1^tm1(cre)Ito mutation (1 available); any Emx1 mutation (31 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

cellular

abnormal Golgi trans cisterna morphology ( J:204664 )

• dilated Golgi cisternae on the trans side of the Golgi stack in hippocampal CA3 pyramidal neurons and dentate gyrus granule cells

nervous system

nervous system phenotype ( J:204664 )

N	• normal synaptic vesicle density and length of postsynaptic density in dentate gyrus granule cells

abnormal dentate gyrus morphology ( J:204664 )

• dilated Golgi cisternae on the trans side of the Golgi stack in dentate gyrus granule cells

• reduction of dense core vesicle density in the presynaptic terminal in dentate gyrus granule cells

abnormal hippocampus pyramidal cell morphology ( J:204664 )

• dilated Golgi cisternae on the trans side of the Golgi stack in hippocampal CA3 pyramidal neurons

abnormal synaptic bouton morphology ( J:204664 )

• reduction of dense core vesicle density in the presynaptic terminal in dentate gyrus granule cells

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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