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Phenotypes Associated with This Genotype
Genotype
MGI:5562536
Allelic
Composition
Chattm2(cre)Lowl/Chat+
Plxna2tm1a(EUCOMM)Wtsi/Plxna2tm1Hfu
Genetic
Background
involves: 129S6/SvEvTac * C57BL/6N * CBA/JNCrlj
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Chattm2(cre)Lowl mutation (4 available); any Chat mutation (63 available)
Plxna2tm1a(EUCOMM)Wtsi mutation (3 available); any Plxna2 mutation (128 available)
Plxna2tm1Hfu mutation (1 available); any Plxna2 mutation (128 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
vision/eye
• the starburst amacrine cell (SAC) processes that normally stratify in 2 discrete inner plexiform laminae (S2 and S4) fail to completely segregate from each other
• disruption of the dendritic plexus organization of On but not Off SACs
• the starburst amacrine cell (SAC) processes that normally stratify in 2 discrete inner plexiform laminae (S2 and S4) fail to completely segregate from each other

nervous system
• the starburst amacrine cell (SAC) processes that normally stratify in 2 discrete inner plexiform laminae (S2 and S4) fail to completely segregate from each other
• disruption of the dendritic plexus organization of On but not Off SACs
• the starburst amacrine cell (SAC) processes that normally stratify in 2 discrete inner plexiform laminae (S2 and S4) fail to completely segregate from each other
• disruption of the dendritic plexus organization of On but not Off SACs


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
01/06/2026
MGI 6.24
The Jackson Laboratory