Phenotypes Associated with This Genotype

Genotype
MGI:5562337

• Allelic Composition: Oprm1^tm1.1Cgrf/Oprm1^tm1.1Cgrf; Scn10a^tm2(cre)Jwo/Scn10a⁺
• Genetic Background: involves: 129 * C57BL/6J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

behavior/neurological

behavior/neurological phenotype ( J:207536 )

N • mice exhibit normal nociception thresholds, morphine-induced antinociception and tolerance to antinociception

abnormal behavioral response to addictive substance ( J:207536 )

• under inflammatory pain, mice exhibit decreased mu opiate-induced analgesia compared with control mice

• under inflammatory pain, mice exhibit decreased analgesia to the peripheral opiate loperamide compared with control mice

homeostasis/metabolism

homeostasis/metabolism phenotype ( J:207536 )

N • morphine-induced constipation is normal

integument

integument phenotype ( J:207536 )

N • mice exhibit normal nociception thresholds, morphine-induced antinociception and tolerance to antinociception