About   Help   FAQ
Phenotypes Associated with This Genotype
Genotype
MGI:5562337
Allelic
Composition
Oprm1tm1.1Cgrf/Oprm1tm1.1Cgrf
Scn10atm2(cre)Jwo/Scn10a+
Genetic
Background
involves: 129 * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Oprm1tm1.1Cgrf mutation (1 available); any Oprm1 mutation (53 available)
Scn10atm2(cre)Jwo mutation (3 available); any Scn10a mutation (102 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
behavior/neurological
N
• mice exhibit normal nociception thresholds, morphine-induced antinociception and tolerance to antinociception
• under inflammatory pain, mice exhibit decreased mu opiate-induced analgesia compared with control mice
• under inflammatory pain, mice exhibit decreased analgesia to the peripheral opiate loperamide compared with control mice

homeostasis/metabolism
N
• morphine-induced constipation is normal

integument
N
• mice exhibit normal nociception thresholds, morphine-induced antinociception and tolerance to antinociception


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support.
last database update
05/28/2024
MGI 6.13
The Jackson Laboratory