Phenotypes Associated with This Genotype

Genotype
MGI:5561200

• Allelic Composition: Hoxa5^tm1.1Ljea/Hoxa5^tm1.1Ljea; Tg(Hoxa5-cre)447BLjea/0
• Genetic Background: involves: 129/Sv * C57BL/6 * CBA * SJL

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

perinatal lethality, incomplete penetrance ( J:207917 )

• about 42% of the pups with the conditional knockout genotype are found dead at birth

• normal Mendelian ratios are found at E18.5

respiratory system

abnormal lung development ( J:207917 )

• at E18.5, lungs display collapsed morphology similar to that observed for Hoxa5^tm1Rob homozygotes

abnormal pulmonary alveolus morphology ( J:207917 )

• enlargement of alveolar spaces is observed in surviving mice at P30, similar to that observed in Hoxa5^-/- animals

abnormal trachea morphology ( J:207917 )

• severe disorganization of the trachea is observed in E18.5 skeletons

respiratory distress ( J:207917 )

• pups display respiratory distress at birth at birth

skeleton

abnormal xiphoid process morphology ( J:207917 )

• process is misshapen at E18.5

increased rib number ( J:207917 )

• extra ribs on cervical vertebra 7 (C7) are observed at E18.5

abnormal cervical vertebrae morphology ( J:207917 )

• absent or shorter tuberculum anterior are observed on C6 at E18.5