Phenotypes Associated with This Genotype

Genotype
MGI:5560912

• Allelic Composition: Tg(APPSwFlLon,PSEN1*M146L*L286V)6799Vas/?
• Genetic Background: involves: C57BL/6 * SJL

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

behavior/neurological

impaired contextual conditioning behavior ( J:208030 )

• decreased % of time freezing in contextual fear conditioning test

impaired cued conditioning behavior ( J:208030 )

• decreased % of time freezing in cued fear conditioning test

abnormal response to novel object ( J:208030 )

• poor novel object recognition

hematopoietic system

increased microglial cell activation ( J:208030 )

• increased percentage of activated microglia as compared to controls

immune system

increased microglial cell activation ( J:208030 )

• increased percentage of activated microglia as compared to controls

nervous system

abnormal astrocyte physiology ( J:208030 )

• increased percentage of reactive astrocytes as compared to controls

increased microglial cell activation ( J:208030 )

• increased percentage of activated microglia as compared to controls

amyloid beta deposits ( J:208030 )

• increased plaque load and size as compared to controls

• high levels of Abeta₄₂ and Abeta₄₀ in the hippocampus as compared to mice that also carry Cdk5r1^tm2.1Lht

abnormal long-term depression ( J:208030 )

• decreased magnitude of long term depression as compared to controls

homeostasis/metabolism

amyloid beta deposits ( J:208030 )

• increased plaque load and size as compared to controls

• high levels of Abeta₄₂ and Abeta₄₀ in the hippocampus as compared to mice that also carry Cdk5r1^tm2.1Lht

cellular

abnormal astrocyte physiology ( J:208030 )

• increased percentage of reactive astrocytes as compared to controls

increased microglial cell activation ( J:208030 )

• increased percentage of activated microglia as compared to controls