Phenotypes Associated with This Genotype

Genotype
MGI:5560900

• Allelic Composition: Cdk5r1^tm2.1Lht/?; Tg(APPSwFlLon,PSEN1*M146L*L286V)6799Vas/?
• Genetic Background: involves: 129S4/SvJaeSor * C57BL/6 * SJL

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

behavior/neurological

behavior/neurological phenotype ( J:208030 )

N • long term depression is restored to wild type levels as compared to mice carrying only Tg(APPSwFlLon,PSEN1*M146L*L286V)6799Vas

N • anxiety, cognitive performance and contextual/cued fear conditioning are restored to wild type levels as compared to mice carrying only Tg(APPSwFlLon,PSEN1*M146L*L286V)6799Vas

nervous system

nervous system phenotype ( J:208030 )

N • presence of reactive astrocytes and activated microglia is close to wild type levels as compared to mice carrying only Tg(APPSwFlLon,PSEN1*M146L*L286V)6799Vas

amyloid beta deposits ( J:208030 )

• plaque load in the hippocampus is reduced as compared to mice with Tg(APPSwFlLon,PSEN1*M146L*L286V)6799Vas alone, but still higher than wild type

• 20-30% reduction of levels of Abeta₄₂ and Abeta₄₀ in the hippocampus as compared to mice carrying only Tg(APPSwFlLon,PSEN1*M146L*L286V)6799Vas

homeostasis/metabolism

amyloid beta deposits ( J:208030 )

• plaque load in the hippocampus is reduced as compared to mice with Tg(APPSwFlLon,PSEN1*M146L*L286V)6799Vas alone, but still higher than wild type

• 20-30% reduction of levels of Abeta₄₂ and Abeta₄₀ in the hippocampus as compared to mice carrying only Tg(APPSwFlLon,PSEN1*M146L*L286V)6799Vas