Phenotypes Associated with This Genotype

Genotype
MGI:5560213

• Allelic Composition: Tg(Vil1-Lin28b,-tdTomato)HiAru/0
• Genetic Background: involves: C57BL/6J * SJL

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

digestive/alimentary system

abnormal intestine goblet cell morphology ( J:202923 )

• in some mice cell numbers are depleted in some regions of both the small intestine and colon

decreased Paneth cell number ( J:202923 )

• severe decrease in the number of Paneth cells

abnormal jejunum crypts of Lieberkuhn morphology ( J:202923 )

• hyperplastic and expanded crypt regions in both adult and weanling jejunum crypts

• increase in apoptosis coincident with the increase in proliferation

increased small intestine adenocarcinoma incidence ( J:202923 )

• the majority of mice develop adenomas or adenocarcinomas at 12-17 months of age

• adenomas and adenocarcinomas are seen in the small intestine only except for in the founder mouse that had tumors in the small intestine and colon at 15.5 months of age

increased intestinal adenoma incidence ( J:202923 )

• the majority of mice develop adenomas or adenocarcinomas at 12-17 months of age

• lesions are typically polyp-shaped or flat

neoplasm

increased small intestine adenocarcinoma incidence ( J:202923 )

• the majority of mice develop adenomas or adenocarcinomas at 12-17 months of age

• adenomas and adenocarcinomas are seen in the small intestine only except for in the founder mouse that had tumors in the small intestine and colon at 15.5 months of age

increased intestinal adenoma incidence ( J:202923 )

• the majority of mice develop adenomas or adenocarcinomas at 12-17 months of age

• lesions are typically polyp-shaped or flat

endocrine/exocrine glands

decreased Paneth cell number ( J:202923 )

• severe decrease in the number of Paneth cells

abnormal jejunum crypts of Lieberkuhn morphology ( J:202923 )

• hyperplastic and expanded crypt regions in both adult and weanling jejunum crypts

• increase in apoptosis coincident with the increase in proliferation

cellular

abnormal intestine goblet cell morphology ( J:202923 )

• in some mice cell numbers are depleted in some regions of both the small intestine and colon