Phenotypes Associated with This Genotype

Genotype
MGI:5560212

• Allelic Composition: Tg(Vil1-Lin28b,-tdTomato)MedAru/0
• Genetic Background: involves: C57BL/6J * SJL

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

digestive/alimentary system

abnormal intestinal mucosa morphology ( J:202923 )

• mucosal hypertrophy

abnormal small intestine morphology ( J:202923 )

• increase in small intestinal mass but no increase in length

abnormal small intestine crypts of Lieberkuhn morphology ( J:202923 )

• crypt proliferation frequently extends downward toward the bottom of the crypts

• increase in apoptosis coincident with the increase in proliferation

decreased Paneth cell number ( J:202923 )

• decrease in the number of Paneth cells

increased small intestine adenocarcinoma incidence ( J:202923 )

• the majority of mice develop adenomas or adenocarcinomas at 12-17 months of age

increased intestinal adenoma incidence ( J:202923 )

• the majority of mice develop adenomas or adenocarcinomas at 12-17 months of age

• lesions are typically polyp-shaped or flat

• adenomas and adenocarcinomas are seen in the small intestine only

neoplasm

increased small intestine adenocarcinoma incidence ( J:202923 )

• the majority of mice develop adenomas or adenocarcinomas at 12-17 months of age

increased intestinal adenoma incidence ( J:202923 )

• the majority of mice develop adenomas or adenocarcinomas at 12-17 months of age

• lesions are typically polyp-shaped or flat

• adenomas and adenocarcinomas are seen in the small intestine only

endocrine/exocrine glands

abnormal small intestine crypts of Lieberkuhn morphology ( J:202923 )

• crypt proliferation frequently extends downward toward the bottom of the crypts

• increase in apoptosis coincident with the increase in proliferation

decreased Paneth cell number ( J:202923 )

• decrease in the number of Paneth cells