Phenotypes Associated with This Genotype

Genotype
MGI:5559723

• Allelic Composition: mgb/mgb
• Genetic Background: involves: FVB/N

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

postnatal lethality, complete penetrance ( J:283803 )

♂ • males die within 1 week of birth

♂ • survival of females is similar to controls

renal/urinary system

hydronephrosis ( J:207566 )

♂

abnormal urinary bladder morphology ( J:283803 )

• thin bladder wall

abnormal urinary bladder detrusor smooth muscle morphology ( J:283803 )

• thin smooth muscle layer

distended urinary bladder ( J:283803 )

• grossly dilated bladders

abnormal urothelium morphology ( J:207566 )

♂ • renal urothelium of severely affected kidneys contains numerous multilayered regions of 3-5 cells throughout the renal pelvis and show frequent cellular blebbing compared to controls that have a single layer of cuboidal cells with intermittent multilayered regions of 2-3 cells

♂ • severely affected kidneys show a 20-fold increase in the percentage of cellular proliferation within the renal urothelium

muscle

abnormal urinary bladder detrusor smooth muscle morphology ( J:283803 )

• thin smooth muscle layer