Phenotypes Associated with This Genotype

Genotype
MGI:5559585

• Allelic Composition: Scrib^tm1.1Cj/Scrib^tm1.1Cj; Tg(Pax6-cre,GFP)1Pgr/0
• Genetic Background: involves: 129S1/Sv * FVB/N

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

vision/eye

iris hyperplasia ( J:204591 )

• hyperplastic, occludes the pupil

abnormal cornea epithelium morphology ( J:204591 )

• irregularly arranged and squamous cells instead of stratified cuboidal cells

abnormal lens morphology ( J:204591 )

• misshapen, small and vacuolated with central opacity

abnormal lens epithelium morphology ( J:204591 )

• squamous rather than cuboidal cells with loss of E-cadherin early in development

• cells acquire mesenchymal traits

cataract ( J:204591 )

• central opacity

small lens ( J:204591 )