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Phenotypes Associated with This Genotype
Genotype
MGI:5559494
Allelic
Composition		 Mus81tm1Chmg/Mus81tm1Chmg
Slx1btm1.1Jrou/Slx1btm1.1Jrou
Genetic
Background		 involves: 129P2/OlaHsd * 129S5/SvEvBrd * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mus81tm1Chmg mutation (0 available); any Mus81 mutation (29 available)
Slx1btm1.1Jrou mutation (0 available); any Slx1b mutation (27 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
reproductive system
reproductive system phenotype ( J:204996 )
N
• mice exhibit normal fertility and testes size

cellular
increased sensitivity to induced cell death ( J:204996 )
• in mouse embryonic fibroblasts treated with DNA interstrand crosslinking agents (MMC) to the same extent as in single homozygotes
• however, MMC-induced increase in sister chromatid exchange frequency is normal in mouse embryonic fibroblasts
abnormal DNA repair ( J:204996 )
• Blm-depleted mouse embryonic fibroblasts exhibit reduced sister chromatid exchange frequency as in single homozygotes

homeostasis/metabolism
abnormal DNA repair ( J:204996 )
• Blm-depleted mouse embryonic fibroblasts exhibit reduced sister chromatid exchange frequency as in single homozygotes

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
03/25/2025
MGI 6.24 		The Jackson Laboratory