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Phenotypes Associated with This Genotype
Genotype
MGI:5559449
Allelic
Composition
Tg(Thy1-APPSweAut)A7Tiwa/0
Genetic
Background
Not Specified
Find Mice Using the International Mouse Strain Resource (IMSR)
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phenotype observed in females
phenotype observed in males
N normal phenotype
nervous system
• develop progressive amyloid deposition in cerebral cortices at around 9-12 months of age
• young (4 month) mutants treated with the anti-amyloid beta antibody 266 exhibit increased levels of monomer amyloid beta species in an antibody-bound form, without affecting that of total amyloid beta

homeostasis/metabolism
• develop progressive amyloid deposition in cerebral cortices at around 9-12 months of age
• young (4 month) mutants treated with the anti-amyloid beta antibody 266 exhibit increased levels of monomer amyloid beta species in an antibody-bound form, without affecting that of total amyloid beta

Mouse Models of Human Disease
OMIM ID Ref(s)
Alzheimer Disease; AD 104300 J:204270


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
06/22/2016
MGI 6.04
The Jackson Laboratory