About   Help   FAQ
Phenotypes Associated with This Genotype
Genotype
MGI:5559229
Allelic
Composition
Tg(APPSwFlLon,PSEN1*M146L*L286V)6799Vas/0
Tg(Thy1-MAPT*)30Schd/0
Genetic
Background
involves: C57BL/6 * C57BL/6J * CBA * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
No mouse lines available in IMSR.
See publication links below for author information.
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• decreased survival at 10 months of age (J:201809)
• decreased survival at 10 months of age (J:201809)

nervous system
• plaque load is reduced compared to mice hemizygous for Tg(APPSwFlLon,PSEN1*M146L*L286V)6799Vas alone (J:201809)
• plaque load is reduced compared to mice hemizygous for Tg(APPSwFlLon,PSEN1*M146L*L286V)6799Vas alone (J:201809)
• at 9 months of age compared to wild-type mice and mice hemizygous for Tg(APPSwFlLon,PSEN1*M146L*L286V)6799Vas alone (J:201809)
• at 9 months of age compared to wild-type mice and mice hemizygous for Tg(APPSwFlLon,PSEN1*M146L*L286V)6799Vas alone (J:201809)
• at 9 months of age (J:201809)
• at 9 months of age (J:201809)
• detected in the hippocampus, cortex, and spinal cord (J:201809)
• tangles in hippocampal neurons are composed of straight filaments with a wavy appearance and of occasional paired helical filaments (J:201809)
• density of tangles in the spinal cord increases strongly from 3 to 9 months of age (J:201809)
• density of tangles in the hippocampus and cortex is increased compared to mice hemizygous for Tg(Thy1-MAPT*)30Schd alone (J:201809)
• age of onset of tangles is earlier compared to mice hemizygous for Tg(Thy1-MAPT*)30Schd alone (J:201809)
• detected in the hippocampus, cortex, and spinal cord (J:201809)
• tangles in hippocampal neurons are composed of straight filaments with a wavy appearance and of occasional paired helical filaments (J:201809)
• density of tangles in the spinal cord increases strongly from 3 to 9 months of age (J:201809)
• density of tangles in the hippocampus and cortex is increased compared to mice hemizygous for Tg(Thy1-MAPT*)30Schd alone (J:201809)
• age of onset of tangles is earlier compared to mice hemizygous for Tg(Thy1-MAPT*)30Schd alone (J:201809)
• dilated dystrophic neurites at 9 months of age (J:201809)
• dilated dystrophic neurites at 9 months of age (J:201809)

behavior/neurological
• at 6 and 8 months of age compared to wild-type mice and mice hemizygous for Tg(APPSwFlLon,PSEN1*M146L*L286V)6799Vas alone (J:201809)
• impairment is more severe than in mice hemizygous for Tg(Thy1-MAPT*)30Schd alone (J:201809)
• at 6 and 8 months of age compared to wild-type mice and mice hemizygous for Tg(APPSwFlLon,PSEN1*M146L*L286V)6799Vas alone (J:201809)
• impairment is more severe than in mice hemizygous for Tg(Thy1-MAPT*)30Schd alone (J:201809)

growth/size/body
• significant and progressive reduction in body weight starting at 6 months of age (J:201809)
• significant and progressive reduction in body weight starting at 6 months of age (J:201809)

homeostasis/metabolism
• plaque load is reduced compared to mice hemizygous for Tg(APPSwFlLon,PSEN1*M146L*L286V)6799Vas alone (J:201809)
• plaque load is reduced compared to mice hemizygous for Tg(APPSwFlLon,PSEN1*M146L*L286V)6799Vas alone (J:201809)

Mouse Models of Human Disease
OMIM ID Ref(s)
Alzheimer Disease; AD 104300 J:201809


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
02/02/2016
MGI 6.02
The Jackson Laboratory