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Phenotypes Associated with This Genotype
Genotype
MGI:5559229
Allelic
Composition
Tg(APPSwFlLon,PSEN1*M146L*L286V)6799Vas/0
Tg(Thy1-MAPT*)30Schd/0
Genetic
Background
involves: C57BL/6 * C57BL/6J * CBA * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tg(APPSwFlLon,PSEN1*M146L*L286V)6799Vas mutation (2 available)
Tg(Thy1-MAPT*)30Schd mutation (0 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• decreased survival at 10 months of age

nervous system
• plaque load is reduced compared to mice hemizygous for Tg(APPSwFlLon,PSEN1*M146L*L286V)6799Vas alone
• at 9 months of age compared to wild-type mice and mice hemizygous for Tg(APPSwFlLon,PSEN1*M146L*L286V)6799Vas alone
• detected in the hippocampus, cortex, and spinal cord
• tangles in hippocampal neurons are composed of straight filaments with a wavy appearance and of occasional paired helical filaments
• density of tangles in the spinal cord increases strongly from 3 to 9 months of age
• density of tangles in the hippocampus and cortex is increased compared to mice hemizygous for Tg(Thy1-MAPT*)30Schd alone
• age of onset of tangles is earlier compared to mice hemizygous for Tg(Thy1-MAPT*)30Schd alone
• dilated dystrophic neurites at 9 months of age

behavior/neurological
• at 6 and 8 months of age compared to wild-type mice and mice hemizygous for Tg(APPSwFlLon,PSEN1*M146L*L286V)6799Vas alone
• impairment is more severe than in mice hemizygous for Tg(Thy1-MAPT*)30Schd alone

growth/size/body
• significant and progressive reduction in body weight starting at 6 months of age

homeostasis/metabolism
• plaque load is reduced compared to mice hemizygous for Tg(APPSwFlLon,PSEN1*M146L*L286V)6799Vas alone

Mouse Models of Human Disease
OMIM ID Ref(s)
Alzheimer Disease; AD 104300 J:201809


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
02/16/2017
MGI 6.07
The Jackson Laboratory