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Phenotypes Associated with This Genotype
Genotype
MGI:5559229
Allelic
Composition
Tg(APPSwFlLon,PSEN1*M146L*L286V)6799Vas/0
Tg(Thy1-MAPT*)30Schd/0
Genetic
Background
involves: C57BL/6 * C57BL/6J * CBA * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
No mouse lines available in IMSR.
See publication links below for author information.
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• decreased survival at 10 months of age

nervous system
• plaque load is reduced compared to mice hemizygous for Tg(APPSwFlLon,PSEN1*M146L*L286V)6799Vas alone
• at 9 months of age compared to wild-type mice and mice hemizygous for Tg(APPSwFlLon,PSEN1*M146L*L286V)6799Vas alone
• detected in the hippocampus, cortex, and spinal cord
• tangles in hippocampal neurons are composed of straight filaments with a wavy appearance and of occasional paired helical filaments
• density of tangles in the spinal cord increases strongly from 3 to 9 months of age
• density of tangles in the hippocampus and cortex is increased compared to mice hemizygous for Tg(Thy1-MAPT*)30Schd alone
• age of onset of tangles is earlier compared to mice hemizygous for Tg(Thy1-MAPT*)30Schd alone
• dilated dystrophic neurites at 9 months of age

behavior/neurological
• at 6 and 8 months of age compared to wild-type mice and mice hemizygous for Tg(APPSwFlLon,PSEN1*M146L*L286V)6799Vas alone
• impairment is more severe than in mice hemizygous for Tg(Thy1-MAPT*)30Schd alone

growth/size/body
• significant and progressive reduction in body weight starting at 6 months of age

homeostasis/metabolism
• plaque load is reduced compared to mice hemizygous for Tg(APPSwFlLon,PSEN1*M146L*L286V)6799Vas alone

Mouse Models of Human Disease
OMIM ID Ref(s)
Alzheimer Disease; AD 104300 J:201809


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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
09/20/2016
MGI 6.05
The Jackson Laboratory