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Phenotypes Associated with This Genotype
Genotype
MGI:5559203
Allelic
Composition
Ntf3tm1Par/Ntf3tm2Jae
Tg(Tagln-cre)1Her/0
Genetic
Background
involves: 129S1/Sv * C57BL/6 * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ntf3tm1Par mutation (0 available); any Ntf3 mutation (22 available)
Ntf3tm2Jae mutation (1 available); any Ntf3 mutation (22 available)
Tg(Tagln-cre)1Her mutation (2 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
behavior/neurological
• mice exhibit increased meal duration with reduced rate of food intake compared with control mice
• mice exhibit a satiation deficit compared with control mice
• however, mice exhibit normal meal size and oropharyngeal-positive feedback signaling

nervous system
• mice exhibit reduced solitary tract nucleus and area postrema meal-induced c-Fos activation, suggesting a decrease in vagal afferent signaling, compared with control mice

growth/size/body
N
• mice exhibit normal body weight


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
03/25/2025
MGI 6.24
The Jackson Laboratory