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Phenotypes Associated with This Genotype
Genotype
MGI:5559172
Allelic
Composition		 Dgcr8Gt(XG058)Byg/Dgcr8+
Genetic
Background		 B6.129P2-Dgcr8Gt(XG058)Byg
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Dgcr8Gt(XG058)Byg mutation (1 available); any Dgcr8 mutation (69 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
nervous system
abnormal neuronal migration ( J:201966 )
• decrease in the chemotactic responsiveness of medial ganglionic eminence derived cells to CXCL12
• migration defect in dentate precursor cells in the hippocampus
abnormal brain interneuron morphology ( J:201966 )
• distribution is altered at E18.5
decreased dentate gyrus size ( J:201966 )
• decrease in volume at P0

cellular
abnormal neuronal migration ( J:201966 )
• decrease in the chemotactic responsiveness of medial ganglionic eminence derived cells to CXCL12
• migration defect in dentate precursor cells in the hippocampus

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
07/08/2026
MGI 6.24 		The Jackson Laboratory