Phenotypes Associated with This Genotype

Genotype
MGI:5559038

• Allelic Composition: Shank3^tm1.2Bux/Shank3^tm1.2Bux
• Genetic Background: 129S6.B6(Cg)-Shank3^tm1.2Bux

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

lethality, incomplete penetrance ( J:206790 )

• fewer than expected homozygotes (16.22%) were produced from a heterozygote x heterozygote cross

• Background Sensitivity: homozygote lethality is background dependent, the greatest loss is observed on the 129S6 background, followed by FVB/N and C57BL/6

behavior/neurological

behavior/neurological phenotype ( J:206790 )

N • Background Sensitivity: tail flick latency is observed in mice on the C57BL/6 background, but not on FVB/N or 129S6/SvEvTac backgrounds

abnormal conditioned emotional response ( J:206790 )

• decreased freezing is observed following 3 tone-shock associations and after third association, however no significant differences are observed in contextual or cued conditioning tests

decreased anxiety-related response ( J:206790 )

• open arc entries are increased in elevated zero-maze as compared to littermate controls

decreased grip strength ( J:206790 )

• mice exhibit decrease in mean forelimb grip strength as compared to littermate controls

increased locomotor activity ( J:206790 )

• mice exhibit hyperactivity in first 10 minutes of open field test, but return to activity level similar to controls

growth/size/body

decreased body weight ( J:206790 )

• mice exhibit lower body weight than controls