Phenotypes Associated with This Genotype

Genotype
MGI:5558938

• Allelic Composition: Megf8^{Gt(G037A09)Wrst}/Megf8^{Gt(G037A09)Wrst}
• Genetic Background: involves: 129S6/SvEvTac * C57BL/6J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

lethality throughout fetal growth and development, complete penetrance ( J:206541 )

• mice die by E16.5

cardiovascular system

cardiovascular system phenotype ( J:206541 )

N • at early stages, mice exhibit normal endocardial cushion mesenchymal cells

abnormal cardiac outflow tract development ( J:206541 )

• transposition

abnormal direction of heart looping ( J:206541 )

• left-right inversion of heart looping in one third of mice

abnormal atrioventricular valve morphology ( J:206541 )

abnormal mitral valve morphology ( J:206541 )

• complete or nearly complete absence of the mitral valve

abnormal tricuspid valve morphology ( J:206541 )

• complete or nearly complete absence of the tricuspid valve

abnormal heart atrium morphology ( J:206541 )

• swollen atria

atrial septal defect ( J:206541 )

ventricular septal defect ( J:206541 )

heart right ventricle outflow tract stenosis ( J:206541 )

• pulmonary stenosis

skeleton

abnormal thoracic cage morphology ( J:206541 )

• wider and shorter than in wild-type mice

split sternum ( J:206541 )

delayed bone ossification ( J:206541 )

• in the rib cage

limbs/digits/tail

abnormal autopod morphology ( J:206541 )

• duplication of bones in the hand

preaxial polydactyly ( J:206541 )

• pre-axial in both the forelimbs and hindlimbs with 6 to 7 digits per limb

embryo

abnormal direction of embryo turning ( J:206541 )

• left-right inversion of embryonic turning in one third of mice

homeostasis/metabolism

edema ( J:206541 )

• severe peripheral edema