Phenotypes Associated with This Genotype

Genotype
MGI:5558066

• Allelic Composition: Col1a1^{tm1(tetO-cre)Haho}/?; Gfi1b^tm1.1Haho/Gfi1b^tm1.1Haho
• Genetic Background: involves: 129S4/SvJaeSor * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

postnatal lethality, complete penetrance ( J:207446 )

• doxycycline activation of cre-mediated excision in animals 4-8 weeks of age is lethal in less than 3 weeks

hematopoietic system

abnormal megakaryocyte differentiation ( J:207446 )

• no mature megakaryocytes are detected in bone marrow

anemia ( J:207446 )

absent erythroid progenitor cell ( J:207446 )

• after induction, no erythroid precursors at or beyond the proerythroblast (monopotent progenitors) stage are detected in the bone marrow

abnormal megakaryocyte progenitor cell morphology ( J:207446 )

• numbers of bipotent megakaryocyte and erythrocyte progenitor cells (pre-MegEs) are increased in bone marrow

decreased hemoglobin content ( J:207446 )

• moribund animals have hemoglobin levels of 1-2 g/dl

thrombocytopenia ( J:207446 )

• moribund animals have severe thrombocytopenia; some animals have no detectable platelets

absent platelets ( J:207446 )

• in some animals

cellular

abnormal megakaryocyte differentiation ( J:207446 )

• no mature megakaryocytes are detected in bone marrow