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Phenotypes Associated with This Genotype
Genotype
MGI:5558028
Allelic
Composition
Scn11atm1.1Ikth/Scn11a+
Genetic
Background
involves: 129 * BALB/c * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Scn11atm1.1Ikth mutation (0 available); any Scn11a mutation (51 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
nervous system
• dorsal ganglion neurons exhibit a shifted resting membrane potential indicating active channels under resting conditions compared with wild-type cell
• diminished peak current densities at depolarized voltage
• greater inward current under resting conditions
• reduced in dorsal ganglion neurons
• less pronounced in dorsal ganglion neurons
• intermediately diminished peak current densities at depolarized voltage

integument
N
• prior to induction of inflammation, mice exhibit normal withdrawal threshold for plantar mechanical and thermal stimulation
• after zymogen-induced inflammation, mice exhibit a smaller reduction in the withdrawal threshold, indicating less thermal and mechanical hyperalgesia, and less protective behavior compared with wild-type mice
• severe, self-inflicted tissue lesions in some mice

behavior/neurological
• after zymogen-induced inflammation, mice exhibit a smaller reduction in the withdrawal threshold, indicating less thermal and mechanical hyperalgesia, and less protective behavior compared with wild-type mice

Mouse Models of Human Disease
DO ID OMIM ID(s) Ref(s)
hereditary sensory neuropathy DOID:0050548 OMIM:PS162400
J:206848


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
04/09/2019
MGI 6.13
The Jackson Laboratory