Phenotypes Associated with This Genotype

Genotype
MGI:5557986

• Allelic Composition: Gt(ROSA)26Sor^{tm1(tetO-Sox9)Msan}/Gt(ROSA)26Sor⁺; Tg(SFTPC-rtTA)5Jaw/0
• Genetic Background: Not Specified

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

perinatal lethality, complete penetrance ( J:202984 )

• when dox treatment was started at E15.5, all 3 double mutants died at birth

respiratory system

abnormal pulmonary alveolus epithelium morphology ( J:202984 )

• in dox treated mice, distal epithelium remains columnar failing to undergo the columnar to squamous transition

cellular

abnormal cell differentiation ( J:202984 )

• when dox treatment is started at E9.5 or E15.5, terminal differentiation of airway cells is inhibited and all differentiated cells are Sox9-negative