Phenotypes Associated with This Genotype

Genotype
MGI:5556193

• Allelic Composition: Mgp^tm1Kry/Mgp^tm1Kry
• Genetic Background: involves: 129S7/SvEvBrd

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

cellular

abnormal osteoblast physiology ( J:203924 )

• osteoblast function is impaired

• 2-fold increase of deposited minerals are seen in calvarial osteoblast cultures

growth/size/body

decreased body size ( J:203924 )

slow postnatal weight gain ( J:203924 )

• poor weight gain during the post-weaning period

cardiovascular system

abnormal artery morphology ( J:203924 )

• abnormal thickening and excessive branching of arteries in the lumbar vertebrae

calcified artery ( J:203924 )

• severe vascular calcification is seen at 5 weeks of age

homeostasis/metabolism

increased circulating osteocalcin level ( J:203924 )

• mild but significant increase in serum levels of osteocalcin

skeleton

decreased bone volume ( J:203924 )

• almost 25% decrease in vertebral bone volume

decreased bone trabecula number ( J:203924 )

decreased trabecular bone thickness ( J:203924 )

• reduction of trabecular thickness in vertebrae at 5 weeks of age

decreased bone mass ( J:203924 )

decreased compact bone mass ( J:203924 )

• at 5 weeks of age

decreased trabecular bone mass ( J:203924 )

• at 5 weeks of age

abnormal epiphyseal plate morphology ( J:203924 )

• premature calcification of the growth plate cartilages in the long bones and vertebrae

decreased bone ossification ( J:203924 )

• decrease in mineral apposition rate and bone formation rate/bone surface ratio, indicating reduction in bone formation

abnormal bone remodeling ( J:203924 )

• bone volume/tissue volume ratio (BV/TV) and trabecular numbers are reduced, indicating abnormal bone remodeling

abnormal osteoblast physiology ( J:203924 )

• osteoblast function is impaired

• 2-fold increase of deposited minerals are seen in calvarial osteoblast cultures