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Phenotypes Associated with This Genotype
Genotype
MGI:5556059
Allelic
Composition		 Plp1tm1Kan/Y
Tspan2tm1Hbw/Tspan2tm1Hbw
Genetic
Background		 B6.Cg-Tspan2tm1Hbw Plp1tm1Kan
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Plp1tm1Kan mutation (1 available); any Plp1 mutation (15 available)
Tspan2tm1Hbw mutation (0 available); any Tspan2 mutation (11 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
nervous system
astrocytosis ( J:201143 )
• severe reactive astrogliosis in the hippocampal fimbria
• enhanced compared to single mutants
microgliosis ( J:201143 )
• increased density of microglia in the hippocampal fimbria
• microglial cells appear to be phagocytic based on presence of inflated lysosomes
brain inflammation ( J:201143 )
• infiltration of cytotoxic T cells and macrophages in the hippocampal fimbria
axon degeneration ( J:201143 )
• similar to what is seen in mice hemizygous for Plp1tm1Kan alone
axonal spheroids ( J:201143 )
• similar to what is seen in mice hemizygous for Plp1tm1Kan alone
demyelination ( J:201143 )
• moderately dysmyelinated, similar to what is seen in mice hemizygous for Plp1tm1Kan alone

behavior/neurological
hindlimb paralysis ( J:201143 )
• at 40 weeks of age

growth/size/body
decreased body weight ( J:201143 )
• at 4 and 40 weeks of age
• similar to what is seen in mice hemizygous for Plp1tm1Kan alone

skeleton
kyphosis ( J:201143 )
• at 40 weeks of age

immune system
microgliosis ( J:201143 )
• increased density of microglia in the hippocampal fimbria
• microglial cells appear to be phagocytic based on presence of inflated lysosomes
brain inflammation ( J:201143 )
• infiltration of cytotoxic T cells and macrophages in the hippocampal fimbria

hematopoietic system
microgliosis ( J:201143 )
• increased density of microglia in the hippocampal fimbria
• microglial cells appear to be phagocytic based on presence of inflated lysosomes

cellular
astrocytosis ( J:201143 )
• severe reactive astrogliosis in the hippocampal fimbria
• enhanced compared to single mutants
microgliosis ( J:201143 )
• increased density of microglia in the hippocampal fimbria
• microglial cells appear to be phagocytic based on presence of inflated lysosomes

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
01/13/2026
MGI 6.24 		The Jackson Laboratory