Phenotypes Associated with This Genotype

Genotype
MGI:5555959

• Allelic Composition: Parp14^{Gt(OST415485)Lex}/Parp14^{Gt(OST415485)Lex}
• Genetic Background: involves: 129S5/SvEvBrd * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

increased B cell apoptosis ( J:146533 )

• in response to irradiation despite IL4 treatment

decreased B cell proliferation ( J:146533 )

• in response to anti-IgM with IL4 treatment

increased B cell proliferation ( J:146533 )

• 1.4-fold in response to anti-IgM treatment

• however, addition of IL4 fails to further increase proliferation

decreased marginal zone B cell number ( J:146533 )

increased follicular B cell number ( J:146533 )

decreased IgA level ( J:146533 )

• in response to KLH

cellular

increased cellular sensitivity to gamma-irradiation ( J:146533 )

• decreased B cell apoptosis despite IL4 treatment

increased B cell apoptosis ( J:146533 )

• in response to irradiation despite IL4 treatment

decreased B cell proliferation ( J:146533 )

• in response to anti-IgM with IL4 treatment

increased B cell proliferation ( J:146533 )

• 1.4-fold in response to anti-IgM treatment

• however, addition of IL4 fails to further increase proliferation

hematopoietic system

increased B cell apoptosis ( J:146533 )

• in response to irradiation despite IL4 treatment

decreased B cell proliferation ( J:146533 )

• in response to anti-IgM with IL4 treatment

increased B cell proliferation ( J:146533 )

• 1.4-fold in response to anti-IgM treatment

• however, addition of IL4 fails to further increase proliferation

decreased marginal zone B cell number ( J:146533 )

increased follicular B cell number ( J:146533 )

decreased IgA level ( J:146533 )

• in response to KLH