Phenotypes Associated with This Genotype

Genotype
MGI:5555041

• Allelic Composition: Lama5^tm1Lsor/Lama5^tm1Lsor; Tg(Tek-cre)1Ywa/0
• Genetic Background: involves: C57BL/6 * SJL

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

decreased transitional stage T2 B cell number ( J:198783 )

decreased marginal zone B cell number ( J:198783 )

• CD23^low/CD21^high

increased B cell number ( J:198783 )

• CD23^low/CD21^low newly formed B cells

increased transitional stage T1 B cell number ( J:198783 )

increased IgM level ( J:198783 )

• after NP-Ficoll immunization

abnormal marginal zone B cell physiology ( J:198783 )

• increased apoptosis

hematopoietic system

decreased transitional stage T2 B cell number ( J:198783 )

decreased marginal zone B cell number ( J:198783 )

• CD23^low/CD21^high

increased B cell number ( J:198783 )

• CD23^low/CD21^low newly formed B cells

increased transitional stage T1 B cell number ( J:198783 )

increased IgM level ( J:198783 )

• after NP-Ficoll immunization

abnormal marginal zone B cell physiology ( J:198783 )

• increased apoptosis