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Phenotypes Associated with This Genotype
Genotype
MGI:5554544
Allelic
Composition
Fig4plt1/Fig4plt1
Genetic
Background
involves: 129P2/OlaHsd * C3H * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Fig4plt1 mutation (2 available); any Fig4 mutation (33 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
growth/size/body
• relative overgrowth of incisors
• impaired growth; skeleton is normal at birth but is smaller at P21

craniofacial
• craniofacial morphology is altered
• relative overgrowth of incisors

hematopoietic system
• extensive vacuolization is seen in cultures of bone marrow mesenchymal stroma

skeleton
• skeleton is normal at birth but is smaller at P21
• relative overgrowth of incisors
• clavicles are 20-25% smaller at P21 than in wild-type, however their shape is normal
• however, pelvic bone shape is normal in newborns and at P21
• long bones are 20-25% smaller at P21 than in wild-type
• bone volume fraction, bone surface, trabecular number and connectivity density are reduced to less than 50% of wild-type values
• lower cortical density of bones
• femoral cortical thickness is reduced to less than 50% of wild-type values
• extensive vacuolization is seen in cultures of isolated osteoblasts from calvarial tissue
• lower trabecular density of bones and reduction in size and density of trabeculae in vertebrae
• trabecular separation is increased more than 3-fold

limbs/digits/tail
N
• mice do not exhibit aplasia or hypoplasia of digits on the front or rear limb

Mouse Models of Human Disease
DO ID OMIM ID(s) Ref(s)
Yunis-Varon syndrome DOID:0060589 OMIM:216340
J:203638


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
08/13/2019
MGI 6.14
The Jackson Laboratory