Phenotypes Associated with This Genotype

Genotype
MGI:5553271

• Allelic Composition: Ercc1^tm1Jhjh/Ercc1^tm1Jhjh
• Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * FVB/N

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

premature death ( J:206925 )

• mice die between 3 and 4 weeks of age

hematopoietic system

decreased common myeloid progenitor cell number ( J:206925 )

• at 3 weeks

decreased granulocyte monocyte progenitor cell number ( J:206925 )

• decreased colony forming unit-granulocyte (CFU-G) and granulocyte-macrophage (CFU-GM) at 3 weeks

decreased erythroid progenitor cell number ( J:206925 )

• CFU-B at 3 weeks

decreased hematopoietic stem cell number ( J:206925 )

• decreased total LSK+ cells at 3 weeks

decreased megakaryocyte-erythroid progenitor cell number ( J:206925 )

• at 3 weeks

liver/biliary system

abnormal hepatocyte morphology ( J:206925 )

• cells with enlarged nuclei in the liver

growth/size/body

decreased body size ( J:206925 )

decreased body weight ( J:206925 )

• at 3 weeks