Phenotypes Associated with This Genotype

Genotype
MGI:5553174

• Allelic Composition: Helq^{Gt(RRF112)Byg}/Helq^{Gt(RRF112)Byg}
• Genetic Background: involves: 129P2/OlaHsd * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

reproductive system

abnormal spermatogonia morphology ( J:206104 )

♂ • reduced c-Kit+ spermatogonia

ovary atrophy ( J:206104 )

♀

increased ovary tumor incidence ( J:206104 )

♀

increased granulosa cell tumor incidence ( J:206104 )

♀

ovary cyst ( J:206104 )

♀ • cystic hyperplasia

small testis ( J:206104 )

♂

testicular atrophy ( J:206104 )

♂ • varying degree

reduced fertility ( J:206104 )

• females contribute more to reduced fertility than male mice

decreased litter size ( J:206104 )

• mating homozygotes produces fewer and smaller litters than heterozygotes

neoplasm

increased gland tumor incidence ( J:206104 )

• salivary, thyroid, parathyroid, adrenal, mammary and endometrial gland adenomas

increased pituitary adenoma incidence ( J:206104 )

♀

increased mammary gland tumor incidence ( J:206104 )

♀

increased Harderian gland tumor incidence ( J:206104 )

increased ovary tumor incidence ( J:206104 )

♀

increased granulosa cell tumor incidence ( J:206104 )

♀

endocrine/exocrine glands

ovary atrophy ( J:206104 )

♀

ovary cyst ( J:206104 )

♀ • cystic hyperplasia

small testis ( J:206104 )

♂

testicular atrophy ( J:206104 )

♂ • varying degree

increased gland tumor incidence ( J:206104 )

• salivary, thyroid, parathyroid, adrenal, mammary and endometrial gland adenomas

increased pituitary adenoma incidence ( J:206104 )

♀

increased mammary gland tumor incidence ( J:206104 )

♀

increased Harderian gland tumor incidence ( J:206104 )

increased ovary tumor incidence ( J:206104 )

♀

increased granulosa cell tumor incidence ( J:206104 )

♀

nervous system

increased pituitary adenoma incidence ( J:206104 )

♀

integument

increased mammary gland tumor incidence ( J:206104 )

♀

growth/size/body

ovary cyst ( J:206104 )

♀ • cystic hyperplasia

cellular

abnormal spermatogonia morphology ( J:206104 )

♂ • reduced c-Kit+ spermatogonia