Phenotypes Associated with This Genotype

Genotype
MGI:5552967

• Allelic Composition: Apoe^tm1Unc/Apoe^tm1Unc; Klf15^tm2Jain/Klf15^tm2Jain; Tg(Tagln-cre)1Jjl/0
• Genetic Background: involves: 129P2/OlaHsd * FVB/N

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

Klf15^tm2Jain/Klf15^tm2Jain Tg(Tagln-cre)1Jjl/0 Apoe^tm1Unc/Apoe^tm1Unc aortas develop more atherosclerotic lesions after a high fat diet challenge

homeostasis/metabolism

homeostasis/metabolism phenotype ( J:203920 )

N • mice fed a high fat diet exhibit the same circulating levels of cholesterol and triglycerides as in Apoe^tm1Unc homozygotes

immune system

blood vessel inflammation ( J:203920 )

• increased macrophage in the aortic wall and atherosclerotic lesions of mice fed a high fat diet with Apoe^tm1Unc homozygotes

increased macrophage cell number ( J:203920 )

• increased macrophage in the aortic wall and atherosclerotic lesions of mice fed a high fat diet with Apoe^tm1Unc homozygotes

cardiovascular system

increased susceptibility to atherosclerosis ( J:203920 )

• in mice fed a high fat diet compared with Apoe^tm1Unc homozygotes

vascular smooth muscle hypoplasia ( J:203920 )

• decreased vascular smooth muscle cells in the aortic wall and atherosclerotic lesions of mice fed a high fat diet with Apoe^tm1Unc homozygotes

blood vessel inflammation ( J:203920 )

• increased macrophage in the aortic wall and atherosclerotic lesions of mice fed a high fat diet with Apoe^tm1Unc homozygotes

muscle

vascular smooth muscle hypoplasia ( J:203920 )

• decreased vascular smooth muscle cells in the aortic wall and atherosclerotic lesions of mice fed a high fat diet with Apoe^tm1Unc homozygotes

hematopoietic system

increased macrophage cell number ( J:203920 )

• increased macrophage in the aortic wall and atherosclerotic lesions of mice fed a high fat diet with Apoe^tm1Unc homozygotes