Phenotypes Associated with This Genotype

Genotype
MGI:5550270

• Allelic Composition: Ndfip1^{Gt(RRD002)Byg}/Ndfip1^{Gt(RRD002)Byg}
• Genetic Background: involves: 129P2/OlaHsd

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

increased activated T cell number ( J:205692 )

• in the spleen

abnormal T cell physiology ( J:205692 )

• T cells are less dependent on CD28 costimulation than control cells

increased T cell proliferation ( J:205692 )

• following T cell activation in the absence of CD28 costimulation

• regardless of whether IL2 blocking antibodies are present or not

increased interleukin-2 secretion ( J:205692 )

• following T cell activation in the absence of CD28 costimulation

hematopoietic system

increased activated T cell number ( J:205692 )

• in the spleen

abnormal T cell physiology ( J:205692 )

• T cells are less dependent on CD28 costimulation than control cells

increased T cell proliferation ( J:205692 )

• following T cell activation in the absence of CD28 costimulation

• regardless of whether IL2 blocking antibodies are present or not

cellular

increased T cell proliferation ( J:205692 )

• following T cell activation in the absence of CD28 costimulation

• regardless of whether IL2 blocking antibodies are present or not