Phenotypes for Cd151 Itga3 Krt14 MGI:5550138 MGI Mouse

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Phenotypes Associated with This Genotype

Allelic Composition	Cd151^tm2Nki/Cd151^tm2Nki Itga3^tm1Son/Itga3⁺ Krt14^tm1(cre)Wbm/?
Genetic Background	FVB.129P2-Cd151^tm2Nki Itga3^tm1Son Krt14^tm1(cre)Wbm

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cd151^tm2Nki mutation (0 available); any Cd151 mutation (35 available)
Itga3^tm1Son mutation (0 available); any Itga3 mutation (52 available)
Krt14^tm1(cre)Wbm mutation (0 available); any Krt14 mutation (34 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

neoplasm

decreased incidence of tumors by chemical induction ( J:205736 )

• reduced tumor volume and incidents in DMBA- and TPA-treated mice more so than in Cd151^tm2Nki/Cd151^tm2Nki Krt14^tm1(cre)Wbm mice

• however, overall benign and malignant histology is normal

decreased tumor growth/size ( J:205736 )

• reduced tumor volume and incidents in DMBA- and TPA-treated mice more so than in Cd151^tm2Nki/Cd151^tm2Nki Krt14^tm1(cre)Wbm mice

integument

decreased keratinocyte proliferation ( J:205736 )

• in papillomas of DMBA- and TPA-treated mice

homeostasis/metabolism

decreased incidence of tumors by chemical induction ( J:205736 )

• reduced tumor volume and incidents in DMBA- and TPA-treated mice more so than in Cd151^tm2Nki/Cd151^tm2Nki Krt14^tm1(cre)Wbm mice

• however, overall benign and malignant histology is normal

cellular

decreased keratinocyte proliferation ( J:205736 )

• in papillomas of DMBA- and TPA-treated mice

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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