Phenotypes Associated with This Genotype

Genotype
MGI:5550137

• Allelic Composition: Cd151^tm2Nki/Cd151^tm2Nki; Krt14^tm1(cre)Wbm/?
• Genetic Background: FVB.129P2-Cd151^tm2Nki Krt14^tm1(cre)Wbm

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

integument

increased keratinocyte migration ( J:205736 )

• keratinocytes expressing a hair bulge marker are found in the infundibulum and the interfollicular epidermis

• short-term TPA treatment increases the number of keratinocytes expressing a hair bulge marker found in the suprabasal layer

decreased keratinocyte proliferation ( J:205736 )

• in papillomas of DMBA- and TPA-treated mice

abnormal hair follicle morphology ( J:205736 )

• contains fewer long-lived, slow-cycling label-retaining cells (keratinocytes expressing the hair bulge marker)

thin epidermis ( J:205736 )

neoplasm

decreased incidence of tumors by chemical induction ( J:205736 )

• reduced tumor volume and incidents in DMBA- and TPA-treated mice compared with control mice

• however, overall benign and malignant histology is normal

decreased tumor growth/size ( J:205736 )

• reduced tumor volume and incidents in DMBA- and TPA-treated mice compared with control mice

• mildly decreases tumor progression of squamous cell carcinoma induced by DMBA and TPA

homeostasis/metabolism

decreased incidence of tumors by chemical induction ( J:205736 )

• reduced tumor volume and incidents in DMBA- and TPA-treated mice compared with control mice

• however, overall benign and malignant histology is normal

cellular

increased keratinocyte migration ( J:205736 )

• keratinocytes expressing a hair bulge marker are found in the infundibulum and the interfollicular epidermis

• short-term TPA treatment increases the number of keratinocytes expressing a hair bulge marker found in the suprabasal layer

decreased keratinocyte proliferation ( J:205736 )

• in papillomas of DMBA- and TPA-treated mice