Phenotypes Associated with This Genotype

Genotype
MGI:5549944

• Allelic Composition: Cavin2^{tm1(KOMP)Vlcg}/Cavin2^{tm1(KOMP)Vlcg}
• Genetic Background: involves: C57BL/6 * C57BL/6NTac
• Cell Lines: 11065A-H7

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

cardiovascular system

abnormal vascular endothelial cell morphology ( J:205741 )

• lung endothelia contain very few caveolae with more shallow endothelium membrane invagination

• adipose endothelium contains fewer caveolae than in wild-type mice

• however, calveolae in the heart and muscle are normal

abnormal lung vasculature morphology ( J:205741 )

• gaps in the lung capillary

abnormal pulmonary endothelial cell surface ( J:205741 )

• lung endothelia contain very few caveolae with more shallow endothelium membrane invagination

cellular

abnormal plasma membrane morphology ( J:205741 )

• lung endothelia contain very few caveolae

• adipose endothelium and adipocytes contains fewer caveolae than in wild-type mice

• however, calveolae in the heart and muscle are normal

adipose tissue

abnormal fat cell morphology ( J:205741 )

• adipocytes contains fewer caveolae than in wild-type mice

respiratory system

abnormal lung vasculature morphology ( J:205741 )

• gaps in the lung capillary

abnormal pulmonary endothelial cell surface ( J:205741 )

• lung endothelia contain very few caveolae with more shallow endothelium membrane invagination