Phenotypes Associated with This Genotype

Genotype
MGI:5548192

• Allelic Composition: Ctdnep1^tm3Ryn/Ctdnep1^tm3Ryn; Six2^{tm1(tTA,tetO-EGFP/cre)Amc}/Six2⁺
• Genetic Background: involves: 129 * C57BL/6 * C57BL/6J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

premature death ( J:205755 )

• mice begin to die after weaning with all mice dying before 8 weeks of age and a median survival of 33.3 days

renal/urinary system

abnormal kidney morphology ( J:205755 )

• a cavity appears at P14 and expands with age

• however, BMP inhibition rescues kidney defects

small kidney ( J:205755 )

• at P28

decreased kidney weight ( J:205755 )

abnormal nephron morphology ( J:205755 )

• progressive loss of nephron components, including glomeruli, proximal and distal tubules, and the loop of Henle located in the cortex and outer medullary regions

renal glomerulus atrophy ( J:205755 )

• fewer glomeruli at P7 and P14

abnormal proximal convoluted tubule morphology ( J:205755 )

• reduced number of tubules at P21