Phenotypes for Itga2b Rhoa Tg(ITGA2B)3Mako Tg(Pf4-icre)Q3Rsko MGI:5548168 MGI Mouse

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Phenotypes Associated with This Genotype

Allelic Composition	Itga2b^{tm1(GFP/cre)Emam}/Itga2b^{tm1(GFP/cre)Emam} Rhoa^tm1Csab/Rhoa^tm1Csab Tg(ITGA2B)3Mako/0 Tg(Pf4-icre)Q3Rsko/0
Genetic Background	involves: 129S6/SvEvTac * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Itga2b^{tm1(GFP/cre)Emam} mutation (0 available); any Itga2b mutation (45 available)
Rhoa^tm1Csab mutation (0 available); any Rhoa mutation (75 available)
Tg(ITGA2B)3Mako mutation (0 available)
Tg(Pf4-icre)Q3Rsko mutation (1 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

hematopoietic system

abnormal megakaryocyte morphology ( J:204459 )

• cultured megakaryocytes derived from fetal liver E13.5 exhibit altered ploidy distribution (modal ploidy 16N compared with normal 2N) and larger size compared with control cells

• megakaryocytes are stiffer than in control cells

abnormal megakaryocyte differentiation ( J:204459 )

• in vivo platelet production is impaired

decreased megakaryocyte cell number ( J:204459 )

cellular

abnormal megakaryocyte differentiation ( J:204459 )

• in vivo platelet production is impaired

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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