Phenotypes Associated with This Genotype

Genotype
MGI:5548071

• Allelic Composition: Pax7^tm1.1Thbr/Pax7^{tm2.1(cre/ERT2)Fan}
• Genetic Background: involves: 129S1/Sv * 129X1/SvJ

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

muscle

muscle phenotype ( J:202693 )

N • tamoxifen-treated mice do not exhibit centrally localized nuclei or differences in fiber diameter

abnormal skeletal muscle satellite cell proliferation ( J:202693 )

• reduced in tamoxifen-treated cultures

abnormal skeletal muscle morphology ( J:202693 )

• adult mice treated with tamoxifen exhibit rare atypical satellite cells with reduced heterochromatin condensation compared with control mice

decreased skeletal muscle size ( J:202693 )

• in a model of muscle regeneration, tamoxifen- and cardiotoxin-treated mice exhibit reduced total muscle size compared with control mice

decreased satellite cell number ( J:202693 )

• after tamoxifen treatment

• after tamoxifen- and cardiotoxin-treatment

skeletal muscle fibrosis ( J:202693 )

• in a model of muscle regeneration, tamoxifen- and cardiotoxin-treated mice exhibit massive increase in necrotic fibers and fibrotic tissue compared with control mice

skeletal muscle necrosis ( J:202693 )

• in a model of muscle regeneration, tamoxifen- and cardiotoxin-treated mice exhibit massive increase in necrotic fibers and fibrotic tissue compared with control mice

abnormal muscle regeneration ( J:202693 )

• in a model of muscle regeneration, tamoxifen- and cardiotoxin-treated mice exhibit reduced total muscle size and myofiber diameters with massive increase in necrotic fibers and fibrotic tissue compared with control mice

cellular

abnormal skeletal muscle satellite cell proliferation ( J:202693 )

• reduced in tamoxifen-treated cultures