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Phenotypes Associated with This Genotype
Genotype
MGI:5547520
Allelic
Composition		 Myd88tm1Defr/Myd88tm1Defr
Tnip1tm1.2Ama/Tnip1tm1.2Ama
Tg(Itgax-cre)1-1Reiz/0
Genetic
Background		 involves: 129P2/OlaHsd * C57BL/6 * C57BL/6J * CBA
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Myd88tm1Defr mutation (4 available); any Myd88 mutation (51 available)
Tg(Itgax-cre)1-1Reiz mutation (4 available)
Tnip1tm1.2Ama mutation (0 available); any Tnip1 mutation (55 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
hematopoietic system
hematopoietic system phenotype ( J:205446 )
N
• unlike Tnip1tm1.1Ama/Tnip1tm1.1Ama Tg(Itgax-cre)1-1Reiz hematopoietic stem cells used in transplantation experiments, hematopoietic stem cells do not alter susceptibility to IMQ-induced psoriasis

immune system
immune system phenotype ( J:205446 )
N
• unlike Tnip1tm1.1Ama/Tnip1tm1.1Ama Tg(Itgax-cre)1-1Reiz mice, mice exhibit normal spleen mass, myeloid cell numbers and activated T lymphocyte

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
12/30/2025
MGI 6.24 		The Jackson Laboratory