Phenotypes Associated with This Genotype

Genotype
MGI:5547518

• Allelic Composition: Tnip1^tm1.2Ama/Tnip1^tm1.2Ama; Tg(Itgax-cre)1-1Reiz/0
• Genetic Background: involves: C57BL/6 * C57BL/6J * CBA

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

enlarged spleen ( J:205446 )

• by 3 to 4 months with accumulation of myeloid and memory T cells

abnormal leukocyte morphology ( J:205446 )

• increased CD11b+Gr1+ myeloid cells

increased plasmacytoid dendritic cell number ( J:205446 )

• slightly in the spleen

increased memory T cell number ( J:205446 )

• CD4+ and CD8+ memory T cells

enlarged lymph nodes ( J:205446 )

• by 3 to 4 months with accumulation of myeloid and memory T cells

increased interleukin-12 secretion ( J:205446 )

• from bone marrow-derived dendritic cells stimulated with LPS

increased interleukin-23 secretion ( J:205446 )

• from bone marrow-derived dendritic cells stimulated with LPS

increased interleukin-6 secretion ( J:205446 )

• from bone marrow-derived dendritic cells stimulated with LPS

increased tumor necrosis factor secretion ( J:205446 )

• from bone marrow-derived dendritic cells stimulated with LPS

hematopoietic system

enlarged spleen ( J:205446 )

• by 3 to 4 months with accumulation of myeloid and memory T cells

abnormal leukocyte morphology ( J:205446 )

• increased CD11b+Gr1+ myeloid cells

increased plasmacytoid dendritic cell number ( J:205446 )

• slightly in the spleen

increased memory T cell number ( J:205446 )

• CD4+ and CD8+ memory T cells

abnormal hematopoietic stem cell physiology ( J:205446 )

• hematopoietic stem cells transplanted into irradiated recipient mice exhibit increased susceptibility to IMQ-induced psoriasis compared with control cells

growth/size/body

enlarged spleen ( J:205446 )

• by 3 to 4 months with accumulation of myeloid and memory T cells