Phenotypes Associated with This Genotype

Genotype
MGI:5545743

• Allelic Composition: Kit^{tm1(cre/ERT2)Dsa}/Kit⁺; Prkg1^tm2Naw/Prkg1^tm2Naw
• Genetic Background: involves: 129S1/Sv * 129S6/SvEvTac * 129X1/SvJ * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

digestive/alimentary system

abnormal gastrointestinal motility ( J:204737 )

• significant GI motor dysfunction is observed with tamoxifen treatment

abnormal intestinal peristalsis ( J:204737 )

• change in contraction frequency is observed in tamoxifen-treated mutants

• nitric oxide-dependent nitrergic slow component of the inhibitory junction potential in circular smooth muscle cells of the colon is abolished in tamoxifen-treated mice

abnormal intestinal transit time ( J:204737 )

• GI transit time is increased by about 2 hours in treated mutants

muscle

abnormal intestinal peristalsis ( J:204737 )

• change in contraction frequency is observed in tamoxifen-treated mutants

• nitric oxide-dependent nitrergic slow component of the inhibitory junction potential in circular smooth muscle cells of the colon is abolished in tamoxifen-treated mice