Phenotypes Associated with This Genotype

Genotype
MGI:5545742

• Allelic Composition: Gt(ROSA)26Sor^tm1(DTA)Jpmb/Gt(ROSA)26Sor⁺; Kit^{tm1(cre/ERT2)Dsa}/Kit⁺
• Genetic Background: involves: 129S/SvEv * 129S6/SvEvTac * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

digestive/alimentary system

abnormal gastrointestinal motility ( J:204737 )

• significantly disturbed after 3 days of tamoxifen treatment (which results in loss of more than 50% of insterstitial cells of Cajal (ICCs)

abnormal intestinal peristalsis ( J:204737 )

• tamoxifen-treated mice show dysrhythmia resulting from uncoordinated spontaneous contractions and lack of slow-wave type electrical activity

abnormal intestinal transit time ( J:204737 )

• total GI transit time is increased to more than 5 hours; similar transit time is measured in tamoxifen-treated mutants that have been repopulated with wild-type mast cells (by adaptive BM transplant)

impaired gastric peristalsis ( J:204737 )

• tamoxifen-treated mice have delayed gastric emptying

nervous system

abnormal synaptic transmission ( J:204737 )

• in tamoxifen treated mice, excitatory enteric neurotransmission is blocked as result of ICC depletion

muscle

abnormal intestinal peristalsis ( J:204737 )

• tamoxifen-treated mice show dysrhythmia resulting from uncoordinated spontaneous contractions and lack of slow-wave type electrical activity