Phenotypes Associated with This Genotype

Genotype
MGI:5544607

• Allelic Composition: Trpv4^tm1.1Ldtk/Trpv4^tm1.1Ldtk; Tg(KRT14-cre/ERT)20Efu/0
• Genetic Background: involves: C57BL/6 * CD-1 * SJL

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

Tamoxifen-treated Trpv4^tm1.1Ldtk/Trpv4^tm1.1Ldtk Tg(KRT14-cre/ERT)20Efu/0 mice show protection from UVB-induced tissue injury

behavior/neurological

behavior/neurological phenotype ( J:200749 )

N • chemical irritant-induced nocifensive behavior is similar to controls

abnormal mechanical nociception ( J:200749 )

• decrease in sensitivity toward noxious mechanical stimulation 48 hours after UV exposure compared to similarly treated controls

increased thermal nociceptive threshold ( J:200749 )

• decrease in sensitivity toward noxious radiant heat stimulation in tamoxifen treated mice 48 hours after UV exposure compared to similarly treated controls

integument

abnormal skin physiology ( J:200749 )

• no signs of UVB-induced tissue injury are seen in tamoxifen treated mice with complete targeting

• UVB-induced tissue injury maybe moderately less severe in tamoxifen treated mice with incomplete targeting