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Phenotypes Associated with This Genotype
Genotype
MGI:5544476
Allelic
Composition
Pde6brd1/Pde6brd1
Genetic
Background
involves: C3H
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Pde6brd1 mutation (88 available); any Pde6b mutation (118 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
nervous system
• pale at 3.5 weeks of age

vision/eye
• patchy, pigmented appearance at 3.5 weeks of age
• pale at 3.5 weeks of age
• only a single layer of cells is present at 3.5 weeks of age
• degeneration is accelerated compared to mice homozygous for Pde6batrd2
• fail to respond in a visual tracking drum assay at 3.5, 6 and 10 weeks of age
• effectively blind by 3.5 weeks of age

Mouse Models of Human Disease
DO ID OMIM ID(s) Ref(s)
retinitis pigmentosa 40 DOID:0110375 OMIM:613801
J:101336


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
03/24/2020
MGI 6.15
The Jackson Laboratory