Phenotypes Associated with This Genotype

Genotype
MGI:5544422

• Allelic Composition: X/m1Nish
• Genetic Background: involves: C57BL/6N

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

immune system phenotype ( J:204833 )

♂N

decreased T cell proliferation ( J:204833 )

♂

abnormal B cell differentiation ( J:204833 )

♂ • arrest at the prepro-B to pro-B cell transition

♂ • cell intrinsic failure

♂ • however, EBF transfection restores B cell development

decreased immature B cell number ( J:204833 )

♂

abnormal NK cell differentiation ( J:204833 )

♂ • cell intrinsic impairment that cannot be restored by EBF transfection

decreased B cell number ( J:204833 )

♂

decreased B-1 B cell number ( J:204833 )

♂

absent B-1 B cells ( J:204833 )

♂

absent B-2 B cells ( J:204833 )

♂

absent B cells ( J:204833 )

♂ • virtually no B (B1 and B2) cells at 12 weeks

♂ • in castrated mice

decreased NK cell number ( J:204833 )

♂

decreased IgG level ( J:204833 )

♂

decreased IgM level ( J:204833 )

♂

absent Peyer's patches ( J:204833 )

♂

small lymph nodes ( J:204833 )

♂

hematopoietic system

decreased T cell proliferation ( J:204833 )

♂

abnormal B cell differentiation ( J:204833 )

♂ • arrest at the prepro-B to pro-B cell transition

♂ • cell intrinsic failure

♂ • however, EBF transfection restores B cell development

decreased immature B cell number ( J:204833 )

♂

abnormal NK cell differentiation ( J:204833 )

♂ • cell intrinsic impairment that cannot be restored by EBF transfection

decreased B cell number ( J:204833 )

♂

decreased B-1 B cell number ( J:204833 )

♂

absent B-1 B cells ( J:204833 )

♂

absent B-2 B cells ( J:204833 )

♂

absent B cells ( J:204833 )

♂ • virtually no B (B1 and B2) cells at 12 weeks

♂ • in castrated mice

decreased NK cell number ( J:204833 )

♂

decreased IgG level ( J:204833 )

♂

decreased IgM level ( J:204833 )

♂

cellular

decreased T cell proliferation ( J:204833 )

♂