Phenotypes Associated with This Genotype

Genotype
MGI:5544316

• Allelic Composition: Azi2^tm1Aki/Azi2^tm1Aki; Tbkbp1^tm1Aki/Tbkbp1^tm1Aki
• Genetic Background: Not Specified

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

immune system phenotype ( J:204786 )

N • macrophages exhibit normal cytokine responses after retinoic acid-induction gene-I-like receptor (RLR) and TLR stimulation

abnormal dendritic cell physiology ( J:204786 )

• GM-CSF-derived bone marrow-derived dendritic cells stimulated with TLR ligands (including poly(I:C), LPS and CpG DNA) or infection with RNA viruses (including NDV, Flu and EMCV) exhibit impaired IL6 and TNF production compared with wild-type mice

• GM-CSF-derived bone marrow-derived dendritic cells stimulated with NDV infection exhibit reduced IFN-alpha production compared with wild-type cells

decreased interferon-alpha secretion ( J:204786 )

• in GM-CSF-derived bone marrow-derived dendritic cells stimulated with NDV infection

decreased interleukin-6 secretion ( J:204786 )

• in GM-CSF-derived bone marrow-derived dendritic cells stimulated with TLR ligands (including poly(I:C), LPS and CpG DNA) or infection with RNA viruses (including NDV, Flu and EMCV)

decreased tumor necrosis factor secretion ( J:204786 )

• in GM-CSF-derived bone marrow-derived dendritic cells stimulated with TLR ligands (including poly(I:C), LPS and CpG DNA) or infection with RNA viruses (including NDV, Flu and EMCV)