Phenotypes Associated with This Genotype

Genotype
MGI:5544311

• Allelic Composition: Ryr1^tm2.1Itl/?
• Genetic Background: B6.Cg-Ryr1^tm2.1Itl

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

muscle

muscle phenotype ( J:205099 )

N • mice exhibit normal skeletal muscle histology and baseline fast twitch force generation

abnormal skeletal muscle fiber morphology ( J:205099 )

• isoproterenol treated muscles fail to exhibit an increase in calcium transients compared with wild-type muscles

abnormal muscle physiology ( J:205099 )

• treatment with isoproterenol fails to increase twitch force as in wild-type mice

• isoproterenol treated muscle exhibit slower rate of twitch force development compared with wild-type muscle

• however, half-relaxation time is normal following isoproterenol treatment

behavior/neurological

decreased grip strength ( J:205099 )