Phenotypes Associated with This Genotype

Genotype
MGI:5544304

• Allelic Composition: Gjc1^tm1Kwi/Gjc1^tm1Kwi; Tg(Myh6-icre/ERT2)#Wet/0
• Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * FVB/N

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

embryonic lethality during organogenesis, complete penetrance ( J:205110 )

• embryos treated with tamoxifen at E8.5 and E9.5 die beyond E10.5

• however, mice not treated with tamoxifen develop normally

cardiovascular system

cardiovascular system phenotype ( J:205110 )

N • tamoxifen-treated mice do not exhibit spontaneous AV block, supraventricular or ventricular ectopic beats or arrhythmia

abnormal heart electrocardiography waveform feature ( J:205110 )

• tamoxifen-treated mice exhibit prolonged atria-His (AH) interval compared with control mice

prolonged PQ interval ( J:205110 )

• in tamoxifen-treated mice

abnormal sinoatrial node conduction ( J:205110 )

• tamoxifen-treated mice exhibit shorter sinus node recovery rate compared with control mice