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Phenotypes Associated with This Genotype
Genotype
MGI:5544303
Allelic
Composition		 Gjc1tm1Kwi/Gjc1tm1Kwi
Gjd3tm2.1Kwi/Gjd3tm2.1Kwi
Tg(Myh6-icre/ERT2)#Wet/0
Genetic
Background		 involves: 129P2/OlaHsd * C57BL/6 * FVB/N * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gjc1tm1Kwi mutation (1 available); any Gjc1 mutation (33 available)
Gjd3tm2.1Kwi mutation (1 available); any Gjd3 mutation (13 available)
Tg(Myh6-icre/ERT2)#Wet mutation (0 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
mortality/aging ( J:205110 )
N
• tamoxifen-treated mice are viable

cardiovascular system
cardiovascular system phenotype ( J:205110 )
N
• tamoxifen-treated mice exhibit normal heart morphology, equal heart rates, P-wave duration, QRS intervals and QTc intervals without spontaneous AV block, supraventricular or ventricular ectopic beats or arrhythmia
abnormal heart electrocardiography waveform feature ( J:205110 )
• tamoxifen-treated mice exhibit prolonged atria-His (AH) interval and Wenckebach periodicity compared with control mice
prolonged PQ interval ( J:205110 )
• in tamoxifen-treated mice
abnormal sinoatrial node conduction ( J:205110 )
• tamoxifen-treated mice exhibit shorter sinus node recovery rate compared with control mice

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
03/18/2025
MGI 6.24 		The Jackson Laboratory