Phenotypes for Tg(Myh6-cre)2182Mds Wwtr1 Yap1 MGI:5544297 MGI Mouse

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Phenotypes Associated with This Genotype

Allelic Composition	Wwtr1^tm1.1Eno/Wwtr1⁺ Yap1^tm1.1Eno/Yap1^tm1.1Eno Tg(Myh6-cre)2182Mds/0
Genetic Background	involves: 129S/SvEv * FVB/N

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tg(Myh6-cre)2182Mds mutation (3 available)
Wwtr1^tm1.1Eno mutation (0 available); any Wwtr1 mutation (23 available)
Yap1^tm1.1Eno mutation (0 available); any Yap1 mutation (40 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

Cardiomyopathy in Wwtr1^tm1.2Eno/Wwtr1⁺ Yap1^tm1.1Eno/Yap1^tm1.1Eno Tg(Myh6-cre)2182Mds/0 mice

mortality/aging

postnatal lethality, complete penetrance ( J:200670 )

• die by 10 days of age

• lethality is accelerated compared to mutant mice wild type for Wwtr1

cardiovascular system

myocardium hypoplasia ( J:200670 )

• about a 60% decrease in the number of cardiomyocytes

thin myocardium ( J:200670 )

cellular

increased cardiomyocyte apoptosis ( J:200670 )

• in neonates

muscle

myocardium hypoplasia ( J:200670 )

• about a 60% decrease in the number of cardiomyocytes

thin myocardium ( J:200670 )

increased cardiomyocyte apoptosis ( J:200670 )

• in neonates

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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