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Phenotypes Associated with This Genotype
Genotype
MGI:5544296
Allelic
Composition		 Wwtr1tm1.1Eno/Wwtr1tm1.1Eno
Yap1tm1.1Eno/Yap1+
Tg(Myh6-cre)2182Mds/0
Genetic
Background		 involves: 129S/SvEv * FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tg(Myh6-cre)2182Mds mutation (3 available)
Wwtr1tm1.1Eno mutation (0 available); any Wwtr1 mutation (23 available)
Yap1tm1.1Eno mutation (0 available); any Yap1 mutation (40 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype

Cardiomyopathy in Wwtr1tm1.2Eno/Wwtr1tm1.2Eno Yap1tm1.1Eno/Yap1+ Tg(Myh6-cre)2182Mds/0 mice

mortality/aging
premature death ( J:200670 )
• complete lethality by 33 weeks of age from heart failure

cardiovascular system
dilated cardiomyopathy ( J:200670 )
• grossly dilated at 30 weeks of age but seen as early as 8 days of age

homeostasis/metabolism
abnormal atrial thrombosis ( J:200670 )
• at 30 weeks of age

muscle
dilated cardiomyopathy ( J:200670 )
• grossly dilated at 30 weeks of age but seen as early as 8 days of age

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
01/20/2026
MGI 6.24 		The Jackson Laboratory