Phenotypes Associated with This Genotype

Genotype
MGI:5544295

• Allelic Composition: Yap1^tm1.1Eno/Yap1^tm1.1Eno; Tg(Myh6-cre)2182Mds/0
• Genetic Background: involves: 129S/SvEv * FVB/N

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

Lethal cardiomyopathy in Yap1^tm1.1Eno/Yap1^tm1.1Eno Tg(Myh6-cre)2182Mds/0 mice

mortality/aging

premature death ( J:200670 )

• die between 11 and 20 weeks of age from heart failure

cardiovascular system

thin ventricular wall ( J:200670 )

• develops by 9 weeks of age

dilated heart ventricle ( J:200670 )

• mild dilation is seen at 6 weeks of age and becomes more pronounced at 12 weeks of age

cardiac fibrosis ( J:200670 )

• develops in older mice with dilated cardiomyopathy

abnormal cardiovascular system physiology ( J:200670 )

• mild functional heart deficits by 6 weeks of age

dilated cardiomyopathy ( J:200670 )

• develops by 9 weeks of age and worsens with age

decreased cardiac muscle contractility ( J:200670 )

• mild at 6 weeks of age and becomes more pronounced at 12 weeks of age

increased myocardial infarct size ( J:200670 )

• at 26 days after permanent ligation of the left anterior descending coronary artery at P2, mice display a gross deficiency of healthy myocardial tissue throughout the LV free wall and extensive fibrotic infarct zone unlike controls that have fully regenerated by this time

behavior/neurological

lethargy ( J:200670 )

• become lethargic between 11 and 20 weeks of age

respiratory system

respiratory distress ( J:200670 )

• develops between 11 and 20 weeks of age

homeostasis/metabolism

increased myocardial infarct size ( J:200670 )

• at 26 days after permanent ligation of the left anterior descending coronary artery at P2, mice display a gross deficiency of healthy myocardial tissue throughout the LV free wall and extensive fibrotic infarct zone unlike controls that have fully regenerated by this time

abnormal atrial thrombosis ( J:200670 )

• develops in older mice with dilated cardiomyopathy

muscle

dilated cardiomyopathy ( J:200670 )

• develops by 9 weeks of age and worsens with age

decreased cardiac muscle contractility ( J:200670 )

• mild at 6 weeks of age and becomes more pronounced at 12 weeks of age